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Nat Immunol. 2002 Jul;3(7):635-42. Epub 2002 Jun 17.

Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells.

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1
Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, Melbourne 3181, Australia. jason.gill@med.monash.edu.au

Abstract

The epithelial component of the thymic microenvironment is indispensable for the generation of T lymphocytes. Although the heterogeneity of this epithelium is well documented, little is known about precursor-progeny relationships between distinct thymic epithelial lineages. Here we characterized a thymic epithelial cell subpopulation identified by the cell surface glycoprotein MTS24. These cells contained epithelial progenitor cells that were competent and sufficient to fully reconstitute the complex thymic epithelial microenvironment that supported normal T cell development.

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PMID:
12068292
DOI:
10.1038/ni812
[Indexed for MEDLINE]

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