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Invest Radiol. 2002 Jul;37(7):368-75.

Effects of two dimeric iodinated contrast media on renal medullary blood perfusion and oxygenation in dogs.

Author information

1
Guerbet Research, Roissy, France. lanceloe@guerbet-group.com

Abstract

RATIONALE AND OBJECTIVES:

To compare the effects of two iodinated contrast media, iodixanol and ioxaglate, on outer medullary blood flow (MBF) and oxygen tension (MPO(2)) in the dog kidney.

METHODS:

Iodixanol and ioxaglate were injected selectively into the renal artery (320 mgI/kg) of anesthetized Beagle dogs. MBF and MPO(2) were measured with a laser-Doppler probe and an oxygen-sensing microelectrode implanted in the outer medulla. Urine samples were collected for viscosity and osmolality measurements.

RESULTS:

Both contrast media produced a moderate decrease in MBF and MPO(2). The hypoperfusion and hypoxia lasted significantly longer with iodixanol than with ioxaglate. Theophylline, an adenosine receptor antagonist, partially prevented iodixanol-induced hypoxia. Urine viscosity was dramatically increased by iodixanol but not by ioxaglate. Urine osmolality did not differ significantly between groups.

CONCLUSION:

Iodixanol produced a more sustained medullary hypoxia than ioxaglate when injected selectively into the dog renal artery. This may lead to hypoxic cellular damage and subsequent impairment of kidney functions.

PMID:
12068157
[Indexed for MEDLINE]

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