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FEBS Lett. 2002 Jun 19;521(1-3):100-4.

ms1, a novel stress-responsive, muscle-specific gene that is up-regulated in the early stages of pressure overload-induced left ventricular hypertrophy.

Author information

1
Division of Cardiology, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, UK. hm11@leicester.ac.uk

Erratum in

  • FEBS Lett 2002 Sep 25;528(1-3):283.

Abstract

We have identified and characterised a cDNA encoding a novel gene, designated myocyte stress 1 (ms1), that is up-regulated within 1 h in the left ventricle following the application of pressure overload by aortic banding in the rat. The deduced ms1 protein of 317 amino acids contains several putative functional motifs, including a region that is evolutionarily conserved. Distribution analysis indicates that rat ms1 mRNA expression is predominantly expressed in striated muscle and progressively increases in the left ventricle from embryo to adulthood. These findings suggest that ms1 may be important in striated muscle biology and the development of pressure-induced left ventricular hypertrophy.

PMID:
12067735
DOI:
10.1016/s0014-5793(02)02833-8
[Indexed for MEDLINE]
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