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Curr Opin Cell Biol. 2002 Jun;14(3):365-71.

Bi-orienting chromosomes on the mitotic spindle.

Author information

1
School of Life Sciences, University of Dundee, MSI/WTB complex, Dow Street, Dundee DD1 5EH, UK. t.tanaka@dundee.ac.uk

Abstract

For the proper segregation of sister chromatids before cell division, each sister kinetochore must attach to microtubules that extend to opposite spindle poles. This process is called bipolar microtubule attachment or chromosome bi-orientation. The mechanism for chromosome bi-orientation lies at the heart of chromosome segregation, but is still poorly understood. Recent studies suggest that cells can promote bi-orientation by re-orienting kinetochore-spindle pole connections.

PMID:
12067660
DOI:
10.1016/s0955-0674(02)00328-9
[Indexed for MEDLINE]

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