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Curr Opin Cell Biol. 2002 Jun;14(3):336-42.

The mRNA assembly line: transcription and processing machines in the same factory.

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Department of Biochemistry and Molecular Genetics, UCHSC, B121, 4200 East 9th Avenue, Denver, CO 80262, USA.


Processing of RNA precursors to their mature form often occurs co-transcriptionally. Consequently, the ternary complex of DNA template, RNA polymerase and nascent RNA chain is the physiological substrate for factors that modify the nascent RNA by capping, splicing and cleavage/polyadenylation. mRNA production is thought to occur within a "factory" that contains the RNA polymerase II transcription machine and the processing machines. Newly discovered protein-protein contacts between RNA polymerase and factors that process mRNA precursors are beginning to illuminate how the "mRNA factory" works.

[Indexed for MEDLINE]

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