Format

Send to

Choose Destination
See comment in PubMed Commons below
Chest. 2002 Jun;121(6):2072-6.

Progression of idiopathic pulmonary fibrosis in native lungs after single lung transplantation.

Author information

1
Department of Internal Medicine, Division of Pulmonary and Critical Care, Duke University Medical Center, Durham, NC 27710, USA. wahid001@mc.duke.edu

Abstract

This retrospective, single-center study was conducted to assess the response of native idiopathic pulmonary fibrosis (IPF) lungs to a potent cyclosporine-based immunosuppressive regimen in single-lung transplantation recipients. The study included IPF patients who had undergone single-lung transplantation and had chest CT scans before and after transplantation. Five patients underwent single-lung transplantation for IPF between April 1992 and January 2001, and met entry criteria. All patients were placed on an immunosuppressive regimen consisting of prednisone, azathioprine, and cyclosporine. In two of the five patients, ground glass attenuation in the native IPF lung improved post-transplantation. However, fibrotic changes progressed in all five patients. In patients with advanced IPF, a potent cyclosporine-based immunosuppressive regimen is not likely to have an effect on the progression of the disease.

PMID:
12065382
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center