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Blood Cells Mol Dis. 2002 Mar-Apr;28(2):260-74.

Surface antigen changes during normal neutrophilic development: a critical review.

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Division of Hematopathology, Department of Pathology, University of Texas Medical Branch,Galveston, Texas 77555-0743, USA.


Neutrophil surface molecules function in part as biological sensors. Surface antigens undergo several changes during neutrophilic maturation to accommodate the cell's function. Surface antigens may appear with neutrophilic maturation, such as CD16b, CD35, and CD10; disappear with maturation, such as CD49d and CD64; be maintained during maturation, such as CD32, CD59, and CD82; or disappear with maturation but reappear after neutrophilic extravasation, such as CD49b. This article reviews the alterations in surface antigen expression during normal neutrophilic granulopoiesis.

[Indexed for MEDLINE]

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