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J Affect Disord. 2002 Apr;68(2-3):183-90.

Suicide risk in patients with anxiety disorders: a meta-analysis of the FDA database.

Author information

1
Northwest Clinical Research Center, 1900-116th Avenue NE 112, Bellevue, WA 98004, USA. arif@accessone.com

Abstract

BACKGROUND:

Previous reports of suicide risk in patients with anxiety disorders have been inconsistent.

METHODS:

Using the FDA database, we assessed suicide and suicide attempt risk among patients, participating in recent clinical trials evaluating new anti-anxiety medications, with diagnosis of panic disorder (PD), social anxiety disorder or social phobia (SP), generalized anxiety disorder (GAD), post traumatic stress disorder (PTSD), and obsessive compulsive disorder (OCD).

RESULTS:

Overall, among 20076 participating anxious patients, 12 committed suicide and 28 attempted suicide. The annual suicide risk rate was 193/100000 patients and annual suicide attempt risk was 1350/100000 patients.

LIMITATIONS:

Clinical trial data have limited applicability to clinical practice. Participants in clinical trials are a highly selected, nonrepresentative sample of the clinical population. A number of patients never complete clinical trials and thus data are based on a limited sub-sample. These trials were not primarily designed to assess suicide risk.

CONCLUSIONS:

Suicide risk in patients with anxiety disorders is higher than previously thought. Patients with anxiety disorders warrant explicit evaluation for suicide risk.

PMID:
12063146
[Indexed for MEDLINE]

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