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Trends Biotechnol. 2002 Jul;20(7):279-81.

Towards quantitative assays with peptide chips: a surface engineering approach.

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Dept of Chemistry and the Institute for Biophysical Dynamics, The University of Chicago, IL 60637, USA.


The development of peptide and protein microarrays has created enormous opportunities in biomedical research. Current chip-based assays are well suited for identifying candidate protein or enzyme activities but still require conventional solution phase experiments to validate hits. Here, three surface-engineering strategies for microarray design are described and are illustrated in the development of a peptide chip for the quantitative analysis of kinase activity on solid support. These strategies promise to widen the application of microarrays by permitting the evaluation of hits in a chip-based format.

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