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Trends Cell Biol. 2002 May;12(5):226-30.

Joining the cell survival squad: an emerging role for protein kinase CK2.

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Cellular and Molecular Biochemistry Research Laboratory (151), Minneapolis Veterans Affairs Medical Center, Dept Laboratory Medicine and Pathology, MN 55417, USA.


Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the identification of new signaling targets for it have converged to indicate an unexpected function for this protein kinase: cell survival. Here, we summarize our emerging knowledge about how CK2 might participate in the transduction of survival signals.

[Indexed for MEDLINE]

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