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Cell. 2002 May 31;109(5):541-4.

PI 3-kinases and PTEN: how opposites chemoattract.

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PRAT Research Fellowship Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD 20892, USA.


Phosphatidylinositol lipids, such as PI(4,5)P2 and PI(3,4,5)P3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.

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