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Dev Cell. 2002 Jun;2(6):692-4.

Looking over the edge: a new role for Ena/VASP proteins in lamellipodial dynamics.

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  • 1Cell Motility Laboratory, Cancer Research UK.


How can Ena/VASP proteins promote actin-based movement of the intracellular pathogen Listeria or rapid protrusion of lamellipodia but at the same time inhibit cell translocation? A report in the May 17(th) issue of Cell now offers a possible explanation for this conundrum. Bear et al. report that Ena/VASP proteins regulate cell motility by competing with capping proteins to control actin filament length and geometry at the leading edge of cells.

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