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AIDS Read. 2002 May;12(5):222-4.

High doses of riboflavin and thiamine may help in secondary prevention of hyperlactatemia.

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  • 1Pediatric Infectious Diseases Division, Rainbow Babies and Children's Hospital, Western Reserve University, Cleveland, USA.


Lactic acidosis is the most dramatic manifestation of nucleoside reverse transcriptase inhibitor (NRTI)-associated mitochondrial dysfunction. The optimal management of subjects who recover from an episode of lactic acidosis--or its milder form, symptomatic hyperlactatemia--remains unclear. Most physicians opt to restart NRTI-sparing regimens, but such an option may not be available for heavily antiretroviral-experienced patients. Therefore, there is a need to investigate ways to prevent the recurrence of hyperlactatemia in patients who require NRTI-based therapy.

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