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Bratisl Lek Listy. 2002;103(1):22-5.

Decreased consumption of corticosteroids after selenium supplementation in corticoid-dependent asthmatics.

Author information

1
Institute of Preventive and Clinical Medicine, Department of Clinical Immunology, Limbova 14, SK-833 01 Bratislava 37, Slovakia. gazdik@upkm.sk

Abstract

Selenium represents a trace element comprised in enzyme glutathion-peroxidase. It is anti-inflammatory activity is based on the elimination of hydroperoxides produced in the site of inflammation (scavenger of free oxygen radicals). The authors report the results of a pilot study with 17 corticodependent asthmatics (7 females, 10 males) aged 30-74 years, supplemented with the preparation of selenium (Se), in a daily dose of 200 micrograms during the follow-up lasting 96 weeks. We demonstrate the reduced consumption of both inhaled corticosteroids, manifested after 24 to 96 weeks of Se supplementation (SeS) (21.74 mg vs 15.81 mg, p < 0.009, 21.74 mg vs 15.32 mg, p < 0.007, respectively) and systemic corticosteroids after 48 weeks (294 mg vs 78 mg, p < 0.04) and 96 weeks of SeS (294 mg vs 104 mg, p < 0.04). These results correlated with the elevation of Se levels both in plasma and erythrocytes (p < 0.0003, p < 0.0003, respectively). No adverse effects were seen during the study and the tolerance of preparation was good. (Tab. 3, Ref. 17.).

PMID:
12061082
[Indexed for MEDLINE]

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