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Clin Infect Dis. 2002 Jul 1;35(1):96-101. Epub 2002 Jun 6.

Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis.

Author information

1
Department of Internal Medicine, University of Oulu, Oulu, FIN-90014 Oulu, Finland. thautala@sun3.oulu.fi

Abstract

We describe 3 cases of nephropathia epidemica (NE) that confirm that Puumala virus infection may cause hypophyseal injury. Autopsy revealed a hemorrhagic hypophysis positive for Puumala virus antigen in both neuroendocrine stromal and vascular endothelial cells in 1 patient, and 2 patients developed hypophyseal hemorrhage (diagnosed with magnetic resonance imaging) during or shortly after acute NE, both of whom developed panhypopituitarism.

PMID:
12060884
DOI:
10.1086/340859
[Indexed for MEDLINE]

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