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Int J Legal Med. 2002 Apr;116(2):64-7.

Power of exclusion revisited: probability of excluding relatives of the true father from paternity.

Author information

1
Department of Statistics and Actuarial Science, The University of Hong Kong, China. wingfung@hku.hk

Abstract

In parentage testing using DNA markers, the formulae for calculating the probability of exclusion generally overstate the power of a test battery by considering its ability to exclude a random man. It is known that in many cases, in particular immigration applications, the false father is more likely to be a relative, e.g. brother, of the true father than an unrelated man. This work presents formulae that take this consideration into account. A practical example using Hong Kong data is provided to illustrate the effect of the modification. Also discussed is how the expected efficacy of a test battery will be affected when possible mutations and null alleles or genetic inconsistencies are taken into consideration.

PMID:
12056522
[Indexed for MEDLINE]

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