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Int J Legal Med. 2002 Apr;116(2):64-7.

Power of exclusion revisited: probability of excluding relatives of the true father from paternity.

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Department of Statistics and Actuarial Science, The University of Hong Kong, China.


In parentage testing using DNA markers, the formulae for calculating the probability of exclusion generally overstate the power of a test battery by considering its ability to exclude a random man. It is known that in many cases, in particular immigration applications, the false father is more likely to be a relative, e.g. brother, of the true father than an unrelated man. This work presents formulae that take this consideration into account. A practical example using Hong Kong data is provided to illustrate the effect of the modification. Also discussed is how the expected efficacy of a test battery will be affected when possible mutations and null alleles or genetic inconsistencies are taken into consideration.

[Indexed for MEDLINE]

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