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Biochem Biophys Res Commun. 2002 May 24;293(5):1472-7.

Identification and characterization of murine IRAK-M.

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1
Institute of Pharmacology, Hannover Medical School, D-30623 Hannover, Germany.

Erratum in

  • Biochem Biophys Res Commun. 2003 Apr 25;304(1):213.

Abstract

Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have been described. Here we report the identification and characterization of murine IRAK-M (mu-IRAK-M), a mouse homologue to human IRAK-M (hu-IRAK-M). These IRAK-M molecules show 71% sequence identity, a comparable cellular expression, and functional similarities with respect to signal transduction capacity and kinase activity, suggesting functional homology in signalling in human and mouse cells.

PMID:
12054681
DOI:
10.1016/S0006-291X(02)00411-4
[Indexed for MEDLINE]
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