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FEMS Microbiol Lett. 2002 May 21;211(1):105-10.

A mutation in rpoS enhances biofilm formation in Escherichia coli during exponential phase of growth.

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Departamento de Biología Molecular, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, P.O. Box 70-228, 04510, Mexico City, Mexico.


Biofilm formation in Escherichia coli is a process that involves slow growth and stress conditions where several molecular signals and growth phase regulated genes are involved. Here we show that rpoS mutant strains (defective in the stress regulator sigma(S)) exhibit an increased production of biofilm, especially in the exponential phase of growth. Our results indicate that rpoS mutants produce an extracellular factor that promotes the production of biofilm during the exponential phase of growth. Thus, RpoS plays an important role in the regulation of the amount and initiation of biofilm formation in E. coli.

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