Format

Send to

Choose Destination
See comment in PubMed Commons below
Prog Retin Eye Res. 2002 May;21(3):341-58.

LEDGF, a survival factor, activates stress-related genes.

Author information

1
Brigham and Women's Hospital, Department of Ophthalmology, Center for Ophthalmic Research, Harvard Medical School, Boston, MA 02115, USA. tshinohara@rics.bwh.harvard.edu

Abstract

LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.

PMID:
12052388
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center