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Prog Retin Eye Res. 2002 May;21(3):341-58.

LEDGF, a survival factor, activates stress-related genes.

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Brigham and Women's Hospital, Department of Ophthalmology, Center for Ophthalmic Research, Harvard Medical School, Boston, MA 02115, USA.


LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.

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