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Breast Cancer Res. 2002;4(3):95-9. Epub 2002 Apr 18.

Liposome-based drug delivery in breast cancer treatment.

Author information

1
UCSF Comprehensive Cancer Center, San Francisco, California 94115-1710, USA. jpark@cc.ucsf.edu

Abstract

Drug delivery systems can in principle provide enhanced efficacy and/or reduced toxicity for anticancer agents. Long circulating macromolecular carriers such as liposomes can exploit the 'enhanced permeability and retention' effect for preferential extravasation from tumor vessels. Liposomal anthracyclines have achieved highly efficient drug encapsulation, resulting in significant anticancer activity with reduced cardiotoxicity, and include versions with greatly prolonged circulation such as liposomal daunorubicin and pegylated liposomal doxorubicin. Pegylated liposomal doxorubucin has shown substantial efficacy in breast cancer treatment both as monotherapy and in combination with other chemotherapeutics. Additional liposome constructs are being developed for the delivery of other drugs. The next generation of delivery systems will include true molecular targeting; immunoliposomes and other ligand-directed constructs represent an integration of biological components capable of tumor recognition with delivery technologies.

PMID:
12052251
PMCID:
PMC138729
[Indexed for MEDLINE]
Free PMC Article

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