Format

Send to

Choose Destination
See comment in PubMed Commons below
Fungal Genet Biol. 2002 Jun;36(1):1-21.

Predicting the distribution, conservation, and functions of SNAREs and related proteins in fungi.

Author information

1
Biology Department, York University, 4700 Keele Street, Toronto, Ont., Canada M3J 1P3.

Abstract

Hyphal tip growth, the hallmark of the fungi, requires highly polarized and localized exocytosis, but how this requirement is met is unknown. Members of conserved protein families called SNAREs and Rabs mediate vesicle trafficking and fusion at virtually every step of the intracellular pathway in all examined eukaryotes. We have searched the available nearly complete fungal genomes, established the presence or absence of members of the SNARE and Rab families in these genomes, and predicted their evolutionary relationships to one another. Comparisons with the extensively studied Saccharomyces cerevisiae indicate that, in general, most of the members of these families (including those involved in mediating exocytosis) are conserved. The presence of exceptional SNAREs and Rabs in some fungi that are not conserved in S. cerevisiae may be indicative of specialized steps that occur in these fungi. The implications of these findings for current tip growth models are discussed.

PMID:
12051891
DOI:
10.1016/S1087-1845(02)00017-8
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center