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Curr Opin Neurobiol. 2002 Jun;12(3):315-23.

Outside and in: development of neuronal excitability.

Author information

1
Neurobiology Section 0357, Biology Division, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0357, USA.

Abstract

Investigation of the development of excitability has revealed that cells are often specialized at early stages to generate Ca(2+) transients. Studies of excitability have converged on the central role of Ca(2+) and K(+) channels in the plasmalemma that regulate Ca(2+) influx and have identified critical functions for receptor-activated channels in the endoplasmic reticulum that allow efflux of Ca(2+) from intracellular stores. The parallels between excitability in these two locations motivate future work, because comparison of their properties identifies shared attributes.

PMID:
12049939
DOI:
10.1016/s0959-4388(02)00330-6
[Indexed for MEDLINE]

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