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Curr Opin Neurobiol. 2002 Jun;12(3):287-92.

ER transport signals and trafficking of potassium channels and receptors.

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Howard Hughes Medical Institute, Department of Physiology, University of California San Francisco, Box 0725, San Francisco, California 94143-0725, USA.


Channels and receptors on the cell surface mediate neuronal signaling. It is therefore important to understand how their surface density is controlled. Recent studies on the trafficking of potassium channels and neurotransmitter receptors have revealed unexpected complexity in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus, raising the possibility that the surface composition of channels and receptors may be adjusted by controlling their export from the endoplasmic reticulum.

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