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Curr Opin Neurobiol. 2002 Jun;12(3):260-7.

The many faces of p75NTR.

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Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA.


The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new signaling partners, suggest that the numerous biological actions of the neurotrophins via p75(NTR) may reflect selectivity of ligand-receptor interactions and intracellular adaptor protein recruitment.

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