Format

Send to

Choose Destination
Mech Dev. 2002 Jul;115(1-2):101-5.

A naturally occurring alternative product of the mastermind locus that represses notch signalling.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

The mastermind locus encodes a nuclear protein required in the Notch signalling pathway. In a screen for genes affecting wing pattern, we identified an EP element that directs expression of an alternatively spliced form of the mastermind transcript that we call mam[DN]. Unlike the conventional mam transcript, mam[DN] is spatially regulated in the developing embryonic nervous system and eye imaginal disc. mam[DN] corresponds to an endogenous transcript and encodes an alternate form of the Mam protein that dominantly interferes with activity of the conventional Mam protein. Mam[DN] blocks Notch signalling downstream from the activated form of Notch but cannot interfere with an activated form of Su(H), suggesting that Mam[DN] may interfere with the activity of a ternary complex involving Mam, Notch and Su(H).

PMID:
12049771
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center