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Mol Cell. 2002 May;9(5):931-43.

The anaphase-promoting complex: proteolysis in mitosis and beyond.

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Research Institute of Molecular Pathology, Dr.-Bohr Gasse 7, A-1030 Vienna, Austria.


Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.

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