Format

Send to

Choose Destination
Mol Cell. 2002 May;9(5):923-5.

The SCF ubiquitin ligase: an extended look.

Author information

1
Stanford University School of Medicine, Department of Pathology, 300 Pasteur Drive, Palo Alto, CA 94305, USA.

Abstract

The SCF E3 ubiquitin ligases select specific proteins for ubiquitination (and typically destruction) by coupling variable adaptor (F box) proteins that bind protein substrates to a conserved catalytic engine containing a cullin, Cul1, and the Rbx1/Roc1 RING finger protein. A new crystal structure of the SCF(Skp2) ubiquitin ligase shows the molecular organization of this complex and raises important questions as to how substrate ubiquitination is accomplished.

PMID:
12049727
DOI:
10.1016/s1097-2765(02)00538-5
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center