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AAPS PharmSci. 2002;4(1):E4.

Protein binding predictions in infants.

Author information

1
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA. pmcnamar@uky.edu

Abstract

Plasma binding protein levels are lower in the newborn than in the adult and gradually increase with age. At birth, human serum albumin (HSA) concentrations are close to adult levels (75%-80%), while alpha 1-acid glycoprotein (AAG) is initially half the adult concentration. As a result, the extent of drug binding to HSA is closer to that of the adult than are those drugs bound largely to AAG. A model that incorporates the fraction unbound in adults and the ratio of the binding protein concentration between infants and adults successfully predicted the fraction unbound in infants and children.

PMID:
12049488
PMCID:
PMC2751289
DOI:
10.1208/ps040104
[Indexed for MEDLINE]
Free PMC Article

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