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J Am Chem Soc. 2002 Jun 12;124(23):6552-4.

Total synthesis of ecteinascidin 743.

Author information

1
Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, The Japan Science and Technology Cooperation (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Abstract

The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation.

PMID:
12047173
[Indexed for MEDLINE]

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