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Phytomedicine. 2002 Apr;9(3):207-11.

Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats.

Author information

1
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Abstract

Bacopa monniera Wettst. (syn. Herpestis monniera L.; Scrophulariaceae) is a commonly used Ayurvedic drug for mental disorders. The standardized extract was reported earlier to have significant anti-oxidant effect, anxiolytic activity and improve memory retention in Alzheimer's disease. Presently, the standardized methanolic extract of Bacopa monniera (bacoside A - 38.0+/-0.9) was investigated for potential antidepressant activity in rodent models of depression. The effect was compared with the standard antidepressant drug imipramine (15 mg/kg, ip). The extract when given in the dose of 20 and 40 mg/kg, orally once daily for 5 days was found to have significant antidepressant activity in forced swim and learned helplessness models of depression and was comparable to that of imipramine.

PMID:
12046860
DOI:
10.1078/0944-7113-00116
[Indexed for MEDLINE]

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