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J Cell Biochem Suppl. 2002;38:88-95.

Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis.

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Gene Therapy Program, Louisiana State University Health Sciences Center of New Orleans, 70112, USA.


Interleukin 17 (IL-17) is an essential proinflammatory T-cell derived cytokine with various biological actions. IL-17 was found to have a pivotal role in microbial host defense by interconnecting lymphoid and myeloid host defense. It also acts as a stimulatory hematopoietic cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils. This article summarizes results to date on IL-17 research and discusses gene therapy based strategies that were employed to determine its biological functions and significance. A comprehensive working model for IL-17 is introduced.

[Indexed for MEDLINE]

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