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Am Fam Physician. 2002 May 15;65(10):2069-72.

Diagnosis and treatment of Paget's disease of bone.

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Department of Internal Medicine and the Muller Center for Senior Health, Abington Memorial Hospital, Pennsylvania 19001-3788, USA.


Paget's disease of bone (also known as osteitis deformans) is a nonmalignant disease involving accelerated bone resorption followed by deposition of dense, chaotic, and ineffectively mineralized bone matrix. The origin of the disease is unknown, and it is frequently asymptomatic; however, the patient may present with symptoms depending on the bones involved. The most common symptom is pain in the affected bone; neurologic, hearing, vision, cardiac, and oncologic complications are possible. Diagnosis is primarily made by radiographs. Bisphosphonates are the most common treatment.

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