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Rev Saude Publica. 2002 Apr;36(2):180-7.

[Birthweight and caffeine consumption].

[Article in Portuguese]

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Departamento de Pediatria, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brasil.



To assess the association between maternal caffeine consumption during pregnancy and low birth weight, prematurity and intrauterine growth retardation.


A case-control was carried out and 354 newborns of single labor with birthweight <2,500 g (cases) and 354 with birthweight >3,000 g (controls) were analyzed. Caffeine consumption was calculated based on daily consumption of coffee, soft drinks and tea. Results were adjusted using multiple logistic regression for the following confounders: mother's age, schooling, income, marital status, skin color, parity, smoking, previous low birthweight children, mother's pre-pregnancy weight, employment status, interval between pregnancies, prenatal care and high blood pressure.


For caffeine consumption <300 mg/day and >300 mg/day, the adjusted odds ratios for low birthweight were: 0.72 (95%IC=0.45-1.25) and 0.47 (95%IC=0.24-0.92); prematurity: 0.59 (95%IC=0.32-1.09) and 0.32 (95%IC=0.15-0.72); and intrauterine growth retardation: 1.16 (95%IC=0.45-3.01) and 0.64 (95%IC=0.20-1.98), respectively.


There was no association between caffeine consumption during pregnancy and low birthweight, prematurity and intrauterine growth retardation.

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