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Lancet. 2002 May 25;359(9320):1829-31.

Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination.

Author information

1
The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, UK. martin.maiden@zoo.ox.ac.uk

Abstract

The UK was the first place to introduce meningococcal serogroup C conjugate (MCC) vaccines. From November, 1999, all people younger than 18 years, about 14 million individuals, were offered MCC immunisation. The uptake rate was more than 70% by November, 2000. We compared the carriage of meningococci in isolates we obtained from 14,064 students aged 15-17 years during vaccination in 1999, with those from 16,583 students of the same age surveyed 1 year later. Carriage of serogroup C meningococci was reduced by 66% (p=0.004). Our results show that MCC vaccines protect against carriage of meningococci that express serogroup C polysaccharide capsules.

PMID:
12044380
DOI:
10.1016/S0140-6736(02)08679-8
[Indexed for MEDLINE]

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