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Pediatr Nephrol. 2002 May;17(5):370-2.

MPGN type I induced by granulocyte colony stimulating factor.

Author information

1
Pediatric Nephrology Unit, Rambam Medical Center, P.O. Box 9602, Haifa 31096, Israel. d_magen@rambam.health.gov.il

Abstract

We report a girl with severe congenital neutropenia who has received long-term granulocyte-colony stimulating factor (G-CSF) therapy and has developed macroscopic hematuria, proteinuria, and decreased renal function associated with biopsy-proven membranoproliferative glomerulonephritis (MPGN) type I. Temporary discontinuation of G-CSF therapy as well as the use of glycosylated G-CSF has resulted in improvement in renal manifestations. We postulate that the MPGN was G-CSF-induced. Long-term G-CSF therapy should be used with great caution and close surveillance of kidney function.

PMID:
12042897
DOI:
10.1007/s00467-002-0847-9
[Indexed for MEDLINE]

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