Format

Send to

Choose Destination
Nat Med. 2002 Jun;8(6):575-81.

Acute graft-versus-host disease does not require alloantigen expression on host epithelium.

Author information

1
Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, Michigan, USA.

Erratum in

  • Nat Med 2002 Sep;8(9):1039.

Abstract

Alloantigen expression on host antigen-presenting cells (APCs) is essential to initiate graft-versus-host disease (GvHD); therefore, alloantigen expression on host target epithelium is also thought to be essential for tissue damage. We tested this hypothesis in mouse models of GvHD using bone-marrow chimeras in which either major histocompatibility complex class I or class II alloantigen was expressed only on APCs. We found that acute GvHD does not require alloantigen expression on host target epithelium and that neutralization of tumor necrosis factor-alpha and interleukin-1 prevents acute GvHD. These results pertain particularly to CD4-mediated GvHD but also apply, at least in part, to CD8-mediated GvHD. These results challenge current paradigms about the antigen specificity of GvHD effector mechanisms and confirm the central roles of both host APCs and inflammatory cytokines in acute GvHD.

PMID:
12042807
DOI:
10.1038/nm0602-575
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center