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Nat Med. 2002 Jul;8(7):681-6. Epub 2002 Jun 3.

siRNA-directed inhibition of HIV-1 infection.

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  • 1Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Abstract

RNA interference silences gene expression through short interfering 21 23-mer double-strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here we report that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein. siRNAs effectively inhibit pre- and/or post-integration infection events in the HIV-1 life cycle. Thus, siRNAs may have potential for therapeutic intervention in HIV-1 and other viral infections.

PMID:
12042777
DOI:
10.1038/nm725
[PubMed - indexed for MEDLINE]
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