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Nat Rev Mol Cell Biol. 2002 Jun;3(6):441-52.

Adenovirus-5 E1A: paradox and paradigm.

Author information

1
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. sfrisch@burnham-inst.org

Abstract

The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5 E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool with which to study the regulation of fundamental cellular processes.

PMID:
12042766
DOI:
10.1038/nrm827
[Indexed for MEDLINE]

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