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Nat Rev Mol Cell Biol. 2002 Jun;3(6):422-9.

The in vivo functions of ATP-dependent chromatin-remodelling factors.

Author information

1
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mail Stop A1-162, PO Box 19024, Seattle, Washington 98109-1024, USA. ttsukiya@fhcrc.org

Abstract

ATP-dependent chromatin-remodelling factors regulate the accessibility of DNA to nuclear factors that are involved in cellular processes that depend on protein DNA interactions. They probably accomplish this by using the energy of ATP hydrolysis to change the positions of nucleosomes on the DNA, or to change the structure of DNA within the nucleosomes. Although their mechanisms of action have been extensively studied in vitro, many questions remain about their functions in vivo.

PMID:
12042764
DOI:
10.1038/nrm828
[Indexed for MEDLINE]

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