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Am J Psychiatry. 2002 Jun;159(6):895-908.

Defining and quantifying the social phenotype in autism.

Author information

  • 1Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA. ami.klin@yale.edu

Abstract

OBJECTIVE:

Genetic and neurofunctional research in autism has highlighted the need for improved characterization of the core social disorder defining the broad spectrum of syndrome manifestations.

METHOD:

This article reviews the advantages and limitations of current methods for the refinement and quantification of this highly heterogeneous social phenotype.

RESULTS:

The study of social visual pursuit by use of eye-tracking technology is offered as a paradigm for novel tools incorporating these requirements and as a research effort that builds on the emerging synergy of different branches of social neuroscience.

CONCLUSIONS:

Advances in the area will require increased consideration of processes underlying experimental results and a closer approximation of experimental methods to the naturalistic demands inherent in real-life social situations.

Comment in

PMID:
12042174
DOI:
10.1176/appi.ajp.159.6.895
[PubMed - indexed for MEDLINE]
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