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Ital Heart J Suppl. 2002 Mar;3(3):337-43.

[The amiodarone-beta blockers combination could represent an alternative treatment in patients at risk for sudden death in which a benefit from implantable defibrillators has not been clearly demonstrated].

[Article in Italian]

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Divisione di Cardiologia e Centro Aritmologico, Ospedale Civile, Cento, FE.


The combination of amiodarone and beta-blockers appears superior to amiodarone alone in the prevention of sudden death. At present this combination can be proposed to patients at risk of sudden death in whom a beneficial effect of the implantable defibrillator has not been clearly demonstrated. Therefore, the patients who can be treated with this combination appear the following ones: patients with sustained ventricular tachycardia (VT) causing severe hemodynamic compromise and ejection fraction > 35%; patients with hemodynamically well-tolerated sustained VT; patients with ischemic heart disease, syncope of unknown cause and induction of VT or ventricular fibrillation (VF) during electrophysiologic study; patients with sustained VT or VF and age > 80 years; patients with left ventricular dysfunction, without history of sustained VT or VF, but with "symptomatic ventricular arrhythmias".

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