Send to

Choose Destination
See comment in PubMed Commons below
Am J Clin Oncol. 2002 Jun;25(3):289-90.

Timing of G-CSF administration based on the circadian rhythm in patients with ovarian cancer.

Author information

Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.


The aim of this study was to determine the relationship between the timing of granulocyte colony-stimulating factor (G-CSF) administration and its efficacy in patients with chemotherapy-induced granulocytopenia. Twenty patients in whom chemotherapy-induced leukopenia developed after the first course were enrolled in this prospective study. Subjects were randomly divided in two groups according to G-CSF injection time as follows: at 7:00 am and 7:00 pm. Before the G-CSF injection, the plasma G-CSF level for all patients was significantly lower at 7:00 am than that at 7:00 pm. After the injection, plasma G-CSF level did not differ between the two groups. The nadir of the leukocyte was 2,554 +/- 379/mm3 (granulocyte 1,530 +/- 689) for the group injected at 7:00 am, and 2,300 +/- 426/mm3 (granulocyte 1,203 +/- 848) for the group injected at 7:00 pm. The duration of leukocytes less than 2,000/mm3 and granulocytes less than 1,000/mm3 were 2.8 +/- 1.8 days and 3.2 +/- 1.8 days, respectively. Those differences were not significant. The present study showed the circadian rhythm of G-CSF levels in patients with ovarian cancer with chemotherapy-induced granulocytopenia, but there was no remarkable difference depending on administration time.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center