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Science. 2002 May 31;296(5573):1634-5.

TNF-R1 signaling: a beautiful pathway.

Author information

1
Tularik Inc., Two Corporate Drive, South San Francisco, CA 94080, USA. goeddel@tularik.com

Abstract

Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor-1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling complex at the cell membrane. Over the past decade, many of the components and mechanisms of these signaling pathways have been elucidated. We provide an overview of current knowledge of TNF signaling and introduce an STKE Connections Map that depicts a canonical view of this process.

PMID:
12040173
DOI:
10.1126/science.1071924
[Indexed for MEDLINE]

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