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J Neurosci. 2002 Jun 1;22(11):4286-92.

Vascular defects and sensorineural deafness in a mouse model of Norrie disease.

Author information

1
Neurosurgery Service, Massachusetts General Hospital, Boston, Massachusetts 02114, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Norrie disease is an X-linked recessive syndrome of blindness, deafness, and mental retardation. A knock-out mouse model with an Ndp gene disruption was studied. We examined the hearing phenotype, including audiological, histological, and vascular evaluations. As is seen in humans, the mice had progressive hearing loss leading to profound deafness. The primary lesion was localized to the stria vascularis, which houses the main vasculature of the cochlea. Fluorescent dyes showed an abnormal vasculature in this region and eventual loss of two-thirds of the vessels. We propose that one of the principal functions of norrin in the ear is to regulate the interaction of the cochlea with its vasculature.

PMID:
12040033
PMCID:
PMC6758776
DOI:
2002
[Indexed for MEDLINE]
Free PMC Article

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