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Bioorg Med Chem Lett. 2002 Jun 17;12(12):1663-6.

Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.

Author information

1
Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314, USA. jbuynak@mail.smu.edu

Abstract

New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.

PMID:
12039585
DOI:
10.1016/s0960-894x(02)00205-6
[Indexed for MEDLINE]

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