Format

Send to

Choose Destination
Curr Opin Chem Biol. 2002 Apr;6(2):259-73.

Insights into properties and energetics of iron-sulfur proteins from simple clusters to nitrogenase.

Author information

1
Department of Molecular Biology, TPC15, The Scripps Research Institute, La Jolla, California 92037, USA. lou@scripps.edu

Abstract

Some of the principal physical features of iron-sulfur clusters in proteins are analyzed, including metal-ligand covalency, spin polarization, spin coupling, valence delocalization, valence interchange and small reorganization energies, with emphasis on recent spectroscopic and theoretical work. The current state of structural, spectroscopic, and computational knowledge for the iron-sulfur clusters in the nitrogenase iron and iron-molybdenum proteins is examined by comparison and contrast to 'simpler' ironclusters. The differing interactions of the nitrogenase iron and iron-molybdenum clusters compared with those of other iron-sulfur clusters with the protein and solvent environment are also explored.

PMID:
12039013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center