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Curr Opin Chem Biol. 2002 Apr;6(2):145-50.

Lipases as practical biocatalysts.

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1
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim/Ruhr, Germany. reetz@mpi-muelheim.mpg.de

Abstract

Lipases are the most used enzymes in synthetic organic chemistry, catalyzing the hydrolysis of carboxylic acid esters in aqueous medium or the reverse reaction in organic solvents. Recent methodological advancements regarding practical factors affecting lipase activity and enantioselectivity are reviewed. Select practical examples concerning the use of lipases in the production of chiral intermediates are also highlighted.

PMID:
12038997
[Indexed for MEDLINE]
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