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Plant Mol Biol. 2002 Jun-Jul;49(3-4):401-9.

The role of regulated protein degradation in auxin response.

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Institute for Cellular and Molecular Biology, Section of Molecular Cell and Developmental Biology, University of Texas at Austin, USA.


Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCF(TIR1), a ubiquitin protein ligase (E3) result in stabilization of Aux/IAA proteins and decreased auxin response. Further, recent biochemical experiments indicate that the Aux/IAA proteins bind SCF(TIR1) in an auxin-dependent manner.

[Indexed for MEDLINE]

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