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J Perinatol. 2002 Jun;22(4):326-30.

Late-onset group B streptococcal infection in identical twins: insight to disease pathogenesis.

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1
Division of Pediatric Infectious Diseases, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Late-onset group B streptococcal (GBS) infection affecting identical twins is described. Although exhibiting similar signs and symptoms at presentation, twin A suffered fulminant fatal meningitis while twin B recovered completely. The GBS isolates proved to be genetically identical and possessed equivalent abilities to invade and injure cells of the human blood-brain barrier in vitro. Clinical variables associated with the adverse outcome in twin A were longer duration of fever prior to antibiotics and the development of neutropenia. The case histories and experimental data are reviewed to underscore key features of GBS disease pathogenesis.

PMID:
12032798
DOI:
10.1038/sj.jp.7210675
[Indexed for MEDLINE]
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