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J Bacteriol. 2002 Jun;184(12):3392-5.

Formation of dTDP-rhamnose is essential for growth of mycobacteria.

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1
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

Abstract

It was determined that the dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.

PMID:
12029057
PMCID:
PMC135104
[Indexed for MEDLINE]
Free PMC Article
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